EUTrigTreat General Assembly 2014

Keynote Addresses - Project Meeting - BEYOND Symposium

11.-13. June 2014

Berlin, Germany

 

Wednesday, 11 June 2014

 

18:00 – 20:00: Keynote Addresses followed by Reception

                      Meeting room; MERCURE Hotel Berlin City, Invalidenstr. 38; 10115 Berlin

 

Keynote Addresses and Speakers

  • The EUTrigTreat project mission – and beyond
    Prof. Stephan E. Lehnart,
    Coordinator of the EUTrigTreat Consortium
  • The DZHK mission – late preclinical and clinical translation
    Prof. Gerd Hasenfuss
    German Center of Cardiovascular Research (DZHK)
    Clinic of Cardiology & Pulmonology, University Medical Center Goettingen
  • The EHRA perspective
    Prof. Karl-Heinz Kuck
    President of the European Heart Rhythm Association;
    Department of Cardiology, Asklepios Klinik St. Georg, Hamburg
  • The EWGCCE perspective
    Prof. Paul Volders
    European Working Group for Cardiac and Cellular Electrophysiology,
    Maastricht University Medical Centre

Reception

Casual get-together and refreshments

 

 

            Final Project Meeting – What have we achieved?

EUTrigTreat General Assembly VI

 

Thursday, 12 June 2014

Meeting Reception Desk on ground floor

MERCURE Hotel Berlin City, Invalidenstr. 38, 10115 Berlin

A. Janssen: +49 551 39 10574

Hotel:  +49 30 30826931

09:00

Session 1: Diagnostic and Therapeutic Investigations

Chair: M. Vos

09:00

WP1: Arrhythmia risk stratification in a patient cohort

M. Zabel

09:25

WP2: Identification of novel genetic variants

L. Vafiadaki, E. Kranias

09:45

WP3: Imaging arrhythmia signals in intact hearts

M. Mongillo

10:05

WP4: Linking repolarization and arrhythmia risk

G. Smith

10:25

WP5: Low-energy arrhythmia control - LEAP

S. Luther

10:45

Refreshments

 

11:15

Session 2: Genetic and Environmental Mechanisms

Chair: M. Mongillo

11:15

WP6: Arrhythmia triggers and novel biomarkers

S.E. Lehnart

11:35

WP7: Genetic mechanisms of Nav1.5 channel modulation

H. Abriel

11:55

WP8: Novel genetic and environmental mechanisms

E. Kranias

12:15

WP9: Optogenetic models of arrhythmia mechanisms

A. Gottschalk

12:45

Group picture; On-site lunch and refreshments

 

14:00

Session 3: Ion Transport and Disease Mechanisms

Chair: L. Kranias

14:00

WP10: Na+ channels and arrhythmogenic remodeling

I. Baró, F. Charpentier

14:20

WP11: Modeling of arrhythmia mechanisms in the heart

F. Fenton, S. Luther

14:40

WP12: Modeling subcellular arrhythmia mechanisms

W.J. Lederer

15:00

WP13: Targeting a common arrhythmia mechanism

S.E. Lehnart

15:20

Administrative and financial issues

C. Hennecke, S.E. Lehnart

15:45

Coffee break

 

16:15

Session 4: Mechanisms, Models, and Therapy

Chair: S.E. Lehnart

16:15

WP14: Genome-wide mechanism

D. Sanoudou

16:35

WP15: Novel pharmacological approaches

M.v.d. Heyden, M. Vos

16:55

WP16: Ca2+ microdomain regulation by NCX

K. Sipido

17:15

WP17: C. elegans engineering of arrhythmia genes

A. Gottschalk

ca.18:00

Steering Committee meeting

Clinical Trial Steering Panel meeting

S.E. Lehnart & members

M. Zabel & members

19:30

Consortium Dinner(by invitation only)

 

 

 

 

BEYOND symposium organized under the auspices of DZHK

Friday, 13 June 2014 — BEYOND

 

Meeting venue: Deutsches Herzzentrum Berlin

assisted transfer: group leaves hotel lobby at 8:30 AM sharp

Oudenarder Str.17 „Osramhöfe“; use Aufgang A1 (entry door) to level 2; 13347 Berlin-Wedding

09:00

BEYOND – challenges and opportunities

Stephan E. Lehnart

09:05

Translation – the unique approach of the DZHK

Gerd Hasenfuss

09:10

Session 1: Genetic and Cellular Mechanisms

Chair: Michael Gotthardt

09:10

Novel genetic risk markers of calcium handling proteins and sudden death risk in patients

Evangelia Kranias

09:35

Multiple Nav1.5 macromolecular complexes in cardiac cells and inherited arrhythmias

Hugues Abriel

10:00

Why calcium release is a complex problem – nanodomains and arrhythmia triggers

W. Jonathan Lederer

10:30

Coffee break

11:00

Session 2: Population based Studies

Chair: Gerd Hasenfuss

11:00

Personalized Medicine in Cardiology

Heyo K. Kroemer

11:25

Better risk prediction for ICD patients

Markus Zabel

11:50

Towards individual arrhythmia risk – how large population GWAS studies will help patients

Stefan Kääb

12:15

Lunch box break

13:30

Session 3: Electrophysiology Frontiers

Chair: Karin Sipido

13:30

Biophysical characterization of arrhythmia models and drug discovery

Godfrey Smith

14:00

Cellular basis of electrocardiogram risk markers – towards mechanism based diagnosis

Paul Volders

14:30

Session 4: Therapeutic Frontiers

Chair: Paul Volders

14:30

Mission impact - Low Energy Defibrillation Pacing

Stefan Luther

15:00

Towards personalized molecular diagnosis and therapy of arrhythmia

Michael Gotthardt

15:30

BEYOND - Summary and take home points

Stephan E. Lehnart

16:00

Closure & departure