EUTrigTreat General Assembly 2013

5-7 June 2013; Padua, Italy

 

Wednesday, June 5, Opening & Keynote Lecture

16:30

18:00

 

 

19:30

Arrival and Registration; Sala delle Edicole, Piazza Capitaniato 3, 35122 Padova; tel.: +39.049.8274500

Meeting Opening and Introduction - S. E. Lehnart and M. Mongillo

Keynote Lecture: Colin Nichols, Ph.D., Washington University of St. Louis, U.S.

“KATP in the heart: More - or less - than meets the eye!”

Refreshments & Snacks

 

 

EUTrigTreat General Assembly V

5-7 June 2013; Padua, Italy

Thursday, June 6 — Project Meeting Day 1

08:30 Reception desk:

Venetian Institute of Molecular Medicine (VIMM)

Via Giuseppe Orus 2, 35129 Padua

Phone: +39 049 7923211

            +49 551 39 10574 (Anja Janssen)

09:00

Session 1: GENETIC ARRHYTHMIA MODELS

Chair: M. Mongillo

09:00

WP8: ER/SR proteins and arrhythmia susceptibility

(D8.2 m.42, D8.5 m.54)

C. Tzimas, E. Kranias

09:25

WP17: C. elegans engineering for rapid evaluation of human arrhythmia genes (D17.3 m.48, D17.4 m.60)

A. Gottschalk

09:50

WP7: Regulation of the cardiac Nav1.5 channel by SAP97 and the dystrophin-syntrophin complex in mouse models (D7.2 m.24, D7.3 m.54, D7.4 m.60)

Ludovic Gillet

10:15

Poster Session 1

Refreshments

Posters # 1-11 on-screen presentation

Poster judges & Moderation:                           G. Smith & Rik Willems

11:40

Session 2: NOVEL DIAGNOSTIC STRATEGIES

Chair: M. van der Heyden

11:40

WP1: Update on Clinical Trial activities, patient enrolment and statistical analysis (D1.1. m.30/51, D1.2 m.36/53)

M. Zabel, C. Röver

12:05

WP1: Risk prediction by beat-to-beat variability of repolarization (BVR) (D1.2 m.36/53 to D1.4 m.42/53)

R. Varkevisser

12:25

WP1: T-wave alternans (TWA) and clinical implications

(D1.2 m.36/53, D1.3 m.42/53, D1.4 m.42/53)

R. Willems

12:45

WP1: Genetic analysis of patient samples – towards interim data (D1.2 m.36/53 to D1.4 m.42/53)

S.E. Lehnart

13:00

On-site lunch and refreshments

 

14:00

Session 3: ENVIRONMENTAL & METABOLIC MECHANISMS

Chair: K. Sipido

14:00

WP6: Mechanisms of KATP channel modulation in atrial and ventricular cells (D6.3 m.42)

B. Schwappach

14:25

WP14: Genome-wide Ca2+ and stress dependent mechanisms of cardiomyopathy in RyR2-mutant models

(D14.2 m.42 to D14.4 m.52, D14.7 m.54 and D14.8 m.60)

D. Sanoudou, F. Matthes

14:50

WP13: Towards novel inducible NCX targeting in adult heart

(D13.1 & D13.2 each m.38/48; D13.3 m.60)

S. Weber

15:15

Coffee break

 

15:45

Session 4: ION TRANSPORTER MECHANISMS

Chair: C. Nichols

15:45

WP10: Role of the cardiac Na+ channel in arrhythmogenic remodeling (D10.2 m.50, D10.3 m.60)

I. Baró, F. Charpentier

16:10

WP6: Genetic modifiers of ESR Ca2+ uptake and leak in action potential instability (D6.3 m.42)

K. Gusev

16:25

WP11: Computational modeling of Na+ and Ca2+-dependent arrhythmia mechanisms in tissue and heart

(D11.7 to D11.9 each m.42; D11.10 to D11.11 each m60)

F. Fenton

16:50

WP16: Ca2+ microdomain regulation by NCX in rodent and large animal models

(D16.4 m.48, D16.5 to D16.7, each m.48)

K. Sipido

ca. 17:15

Evening Information

M. Mongillo & A. Janssen

17:20

Steering Committee meeting (S.E. Lehnart & members)

Clinical Trial Steering Panel meeting (M. Zabel & members)

VIMM, 2nd floor Room: “Green Room”

VIMM, 2nd floor Room: “Red Room”

19:30

Consortium Dinner

“Caffè Pedrocchi”- Via VIII Febbraio 15, 35122 Padova; Tel.: +39.049.878 1231


 

EUTrigTreat General Assembly V

5-7 June 2013; Padua, Italy

Friday, June 7 – Project Meeting Day 2

Venetian Institute of Molecular Medicine (VIMM)

Via Giuseppe Orus 2, 35129 Padua

Phone: +39 049 7923211

09:00

Session 5: DEFINE THE ARRHYTHMOGENIC SUBSTRATE

Chair: I. Baró

09:00

WP4: Sustained T-wave alternans during an increase in heart rate (D4.4 m.48, D4.5 m.48 and D4.6 m.60)

G. Smith

09:25

WP2: The arrhythmia modifiers HRC and JCN in dilated cardiomyopathy (D2.1 each m.40))

D. Sanoudou/E. Kranias

09:50

WP3: Intracellular calcium signals in the multicellular arrhythmogenic substrate (D.3.4 m.50)

Leonardo Sacconi, Giulia Borile

10:15

Poster Session II

On-Site Coffee Break

Posters #11-21 on-screen presentation

Poster judges & Moderation:                             E. G. Kranias & Hugues Abriel

11:30

Session 6 OPTICAL ARRHYTHMIA STUDIES

Chair: W. J. Lederer

11:30

WP9: Optogenetic studies of C. elegans as surrogate arrhythmia model

(D9.5 to D9.7 each m.48, D9.8 to D9.9 m.60)

A. Gottschalk, M. Mongillo, S. Luther, S.E. Lehnart

11:55

WP6: Cardiac 3D analysis of action potential propagation in transgenic Nav1.5 and RyR2 models (D6.2 m.36/42)

M. Dura, J. Schroeder-Schetelig

12:20

WP3: Voltage imaging by high-speed microscopy

(D3.5 m.36/m.42, D3.7 m.48)

C. de Mauro

12:45

Module 8 update: administrative and financial issues

Group Photo

S. Weber, S.E. Lehnart

13:00

On-site lunch and refreshments

 

14:00

Session 7: ARRHYTHMIA AND EC COUPLING

Chair: G. Smith

14:00

WP12: Heterogeneity of subcellular Ca2+ release

(D12.4 m.48)

S. Jafri

14:25

WP6: Differentmechanisms of stress adaptation in atrial and ventricular EC coupling (D6.3 m.42, D6.5 m.60)

S.E. Lehnart

14:50

WP12: Interrogating subcellular compartments of the myocyte (D12.4 m.48)

W.J. Lederer

15:15

Refreshments

 

15:45

Session 8: NOVEL THERAPEUTIC STRATEGIES

Chair: S.E. Lehnart

15:45

WP15: Developing specific and multi-targeted pharmacological substances

(D15.2 m.48, D15.3 m.60, D15.6 m.48 and D15.7 m.60)

L. Kattner, G. Smith

16:15

WP15: Drug testing in large animal models of arrhythmia (D15.8 m.60)

R. Varkevisser, M. van der Heyden

16:40

WP5: Low-energy EFFP control ov VF – mechanisms and simulations (D5.5/D5.6 each m.36)

S. Luther

17:05

Poster Prizes, Announcements, and Meeting Closure

L. Kranias, H. Abriel, M. Mongillo, S.E. Lehnart

18:00

End of General Assembly; Social Activities or Departure