EUTrigTreat General Assembly 2012

Beatenberg/Bern, Switzerland

June 20-22, 2012

 

NEW INSIGHTS INTO aRRHythmia Physiology and therapeutic goals

Organized by Hugues Abriel and Stephan E. Lehnart

 

SCHEDULE OF EVENTS

Wednesday, June 20

16:30 – 18:00

Registration (Reception desk, Hotel Dorint Blüemlisalp)

18:00 – 19:30

Session I – OPENING & KEYNOTE

 

Opening Remarks (Lecture hall “Blüemlisalpsaal”)

Stephan E. Lehnart, Coordinator - UMG-GOE

Hugues Abriel, Local Host - UBERN

 

Keynote Lecture

André Kléber – Harvard Medical School

Basic mechanisms of cardiac arrhythmias

19:30

Mixer & Buffet Dinner (Hotel Restaurant)

 

 

Thursday, June 21

09:00 – 10:20 

Session II - GENETIC ARRHYTHMIA MODELS (Lecture hall)
Chair: Hugues Abriel – U Bern

09:10 – 09:35

Ludovic Gillet – U Bern (D7.2 m.24, D7.3 m.54)

Regulation of cardiac sodium channels NaV1.5 by SAP97 and the dystrophin-syntrophin complex in mouse models

09:35 – 09:55

Miroslav Dura– UMG Goettingen (D6.2 m.36, D6.3 m.42)

Mechanisms of arrhythmia initiation in CPVT1 and LQTS3 substrate

 

09:55 – 10:20

Litsa Kranias – BRFAA Athens (D8.1 m.18>33, D8.4 m.30>42)

Novel molecular mechanisms of arrhythmia susceptibility

 

10:20 – 11:45

Poster Session I – Arrhythmia mechanisms and targeting

Chairs: Stefan Luther & Evangelia Kranias

Authors at Posters for discussion with attendees and judging for poster competition (3 min presentation & 2 min discussion)

On-site refreshments

11:45 – 12:50

Session III - THE ARRHYTHMOGENIC SUBSTRATE

Chair: Marco Mongillo, U Padua

 

11:45 – 12:10

Alexander Gottschalk – U Frankfurt (D9.4 m.36)

C.elegans as novel surrogate arrhythmia model - multimodal optogenetic studies

 

12:10 – 12:30

Despina Sanoudou – BRFAA Athens (D14.2 m.42, D14.5 m.48)

The arrhythmogenic substrate - deciphering and targeting the molecular mechanisms of pathogenesis in selected mouse models

 

12:30 – 12:50

Falko Matthes – UMG Goettingen (D14.2 m.42)

Sustained stress and the CPVT substrate – towards multifactorial mechanisms

13:00 – 14:00

Lunch (Restaurant)

14:00 – 15:30

Session IV - NOVEL PATIENT STRATEGIES

Chair: Marc Vos - UMC Utrecht

14:00 – 14:20

Markus Zabel – UMG Goettingen (D1.1 m.30>m.36 to D1.4 m.42)

The EUTrigTreat Clinical Trial: enrolment of 632 patients, cardiac electrophysiological testing, and progress towards risk analysis

14:20 – 14:40

Sofieke Wijers – UMC Utrecht (D1.2 m.36)

Beat-to-beat variability of repolarization (BVR) – analyzing patient data for risk prediction

14:40 – 15:00

Vincent Florè – U Leuven (D1.1 m.30>m.36 to D1.4 m.42)

Relationship between T-wave alternans (TWA) and beat-to-beat variability of repolarization (BVR) – implications for the EUTrigTreat Clinical Trial

 

15:00 – 15:15

Stephan E. Lehnart – UMG Goettingen (D1.2 m.36 to D1.4 m.42)

Genetic analysis of patient samples to support risk analysis

 

 

15:15 – 15:30

Klaus Jung – UMG Goettingen (D18.2 m.30>m.42)

Collection and management of patient data, estimated risk after 632 patients, implications for continuation of the trial and statistical analysis

15:30 – 16:00

Coffee break

16:00 – 17:15

Session V - OPTICAL & ANALYTICAL ARRHYTHMIA STUDIES

Chair: Godfrey Smith - U Glasgow

16:00 – 16:25

Marco Mongillo – U Padova (D3.2 m.36, D3.3 m.36)

Cytosolic and intra-SR calcium signals of the arrhythmogenic substrate

 

16:25 – 16:50

Godfrey Smith & Allen Kelly – U Glasgow (D4.3 m.36, D4.4m.48)

Measurements of intramural LV electrophysiology during T-wave alternans

16:50 – 17:15

Leonardo Sacconi – U Florence (D3.5/D3.6 each m.36)

Voltage imaging by high-speed microscopy

 

17:15 – 17:20

Evening Information (Hugues Abriel, Verena Frazao)

17:20 – 18:20

Clinical Trial Steering Panel (members only; “Blüemlisalpsaal”)

17:20 – 18:20

Steering Committee (members only; room “Niesen”)

19:30

Dinner (Restaurant)

 

 

Friday, June 22

09:00 – 10:10

Session VI - GENETIC ARRHYTHMIA MODIFIERS

Chair: W. Jonathan Lederer – U Maryland

09:00 – 09:25

Evangelia Kranias – BRFAA Athens (D2.1&M2.1 each m.40)

HRC and JCN variants as arrhythmia modifiers in dilated cardiomyopathy

09:25 – 09:45

Konstantin Gusev – UMG Goettingen (D6.2 m.36, D6.3 m.42)

Ryanodine receptor mutations and cytosolic calcium removal – exploring molecular mechanisms of dynamic arrhythmia triggers

09:45– 10:10

Alexander Gottschalk – U Frankfurt (D17.2 m.36, D17.3 m.48)
C.elegans as a novel model of human arrhythmia genes analysis

10:10 – 10:30

Module 8 update: Silvio Weber, SE Lehnart – UMG Goettingen

Reporting 2011 and midterm review – the take home message

Administrative and financial issues

10:30 – 11:00

Coffee break + Group photo

11:00 – 12:30

Poster Session II – Arrhythmia Phenotypes & Pathophysiology

Chair: Hugues Abriel & Saleet Jafri

12:30 – 13:30

Lunch (Restaurant)

13:30 – 14:45

Session VII - NOVEL THERAPEUTIC STRATEGIES

Chairs: Stephan E. Lehnart - UMG Goettingen

13:30 – 13:55

Godfrey Smith & Lars Kattner – UGLAS/Endotherm (D15.1 m.24>36)
Automated screening for drug targeting of Ca2+ uptake and release

13:55 – 14:20

Rosanne Varkevisser – UMC Utrecht (D15.8 m.60)

Drug testing in large animal models of arrhythmia

14:20 – 14:45

Stefan Luther – MPI-DS Goettingen (D5.5/D5.6 each m.36)

Low-energy EFFP control of VF – mechanisms and simulations

14:45 – 16:00

Session VIII - IN SILICO ARRHYTHMIA MODELING

Chair: Karin Sipido, K.U.Leuven

14:45 – 15:10

W. Jonathan Lederer – U Maryland (D12.2 m.30, D12.3 m.36, D12.4 m.48)
Whole-cell in silico modeling of Ca2+ triggers and translation to the cardiac  action  potential

15:10 – 15:35

Saleet Jafri – George Mason University (D12.2 m.30, D12.3 m.36)
Whole-cell in silico modeling of Ca2+ triggers and translation to the cardiac action  potential

15:35 – 16:00

Stephan E. Lehnart – U Goettingen (D6.2 and D12.3)

Super-resolution analysis of T-tubule reorganization post-MI and spatial mechanisms of Ca2+ release Dyssynchrony

16:00 – 16:25

Flavio Fenton – Cornell University (D11.6 m.36)
Arrhythmia modeling in the human and mouse heart

 

16:25 – 16:40

Coffee break

16:40 – 17:55

Session IX - Na+ and Ca2+ DEPENDENT MECHANISMS (

Chair: Saleet Jafri, George Mason U & U Maryland

16:40 – 17:05

Karin Sipido – K.U.Leuven (D16.3 m.36 to D16.5 m.48)

Arrhythmogenic Ca2+ regulation of NCX, store filling and threshold modulation

17:05 – 17:30

Silvio Weber – UMG Goettingen (D13.1/D13.2 each m.42)  

In vivo targeting for inducible, reversible NCX knock-out

 

17:30 – 17:55

Isabelle Baró & Flavien Charpentier – INSERM (D10.2 m.50)

The cardiac Na+ channel Nav1.5 – mechanisms of DCM and fibrosis

17:55 – 18:00

Closing remarks - Stephan E. Lehnart, coordinator

18:00

Meeting closure. Participants depart or continue with evening activities

 

18:00                           Optional evening activity: Sunset Dinner on Top of Beatenberg

                                   (only available by pre-registration)