EUTrigTreat General Assembly 2011

June 22-24; Utrecht, The Netherlands

 

Wednesday, June 22, Arrival, Get-Together & Keynote Lecture

16:30

 

18:00

Registration Opens

University of Utrecht, Academy Building

Casual Get-together

Keynote Speaker: Prof. Dr. D.E. Grobbee, University Medical Center Utrecht
Refreshments

 

Thursday, June 23 — 1st Meeting Day

University of Utrecht, Academy Building

Address: Domplein 29, 3512 JE Utrecht

Speaker

Poster ID &

Presenter

9:00

Welcome address

 

M.v.d.Heyden, M. Vos, S. Lehnart

9:10

EUTrigTreat at age 20 (project months): recent achievements and challenges

S. Lehnart

 

9:20

Session 1: Genetic arrhythmia models

Chair: E. Kranias

9:20

WP 7: How dystrophin may contribute to the cardiac action potential (D7.2 m.24)

H. Abriel

P7a: L. Gillet

9:45

WP 6: Conduction disease and arrhythmias: from molecular defect to tissue mechanism (D6.1 m.24)

S. Lehnart

P6a: M. Dura

P6b: K. Gusev

10:10

Poster Session 1

Refreshments

 

First half of posters

11:30

Session 2: The arrhythmogenic substrate

Chair W.J. Lederer

11:30

WP 14: Genome wide pathway analysis of gene environ-ment interactions in the RyR2-R2474S arrhythmogenic substrate. (D14.1 m.24)

F. Matthes

P14a: F. Matthes

11:55

WP 3: Intracellular calcium signals in the multicellular arrhythmogenic substrate (D.3.1 m.24)

M. Mongillo

P3a: M. Mongillo

12:20

On-site food and refreshments

 

 

 

13:15

Session 3: Novel Diagnostic Strategies

Chair M. Vos

13:15

WP 1: Update on multi-centre investigator activities, patient enrolment and phenotyping (D1.1. m.30)

M. Zabel

P1a: M. Zabel, T. Meinel

13:45

WP 1: Heart rate variability (HRV) analysis of the patient ECG for risk prediction (D1.2 m.36)

M. Vos

P1b: -

14:10

WP 1: Patient ECG analysis for low-frequency periodic changes (D1.2 m.36 & D4.7 m.60)

G. Smith

P1c: -

14:20

Poster Session 2

Refreshments

Second half of posters

15:50

Session 4: Optical arrhythmia studies

Chair: G. Smith

15:50

WP 9: Optogenetic studies of C. elegans as surrogate arrhythmia model (D9.2 m.24)

A. Gottschalk

P9a: A. Gottschalk, E. Fischer

16:15

WP 9: Optical modulation of the cardiac myocyte membrane potential (D9.3 m.24)

M. Mongillo

P9b: M. Mongillo

16:40

WP4: Sustained T-wave alternans during an increase in heart rate (D4.1 & D4.2 each m.24)

G. Smith

P4a: A. Kelly, G. Smith

P4b: A. Kelly, G. Smith

17:05

WP3: Voltage imaging by high-speed microscopy (D3.5 & D3.6 each m.36)

Leonardo Sacconi

P3b: C. d. Mauro

P3c: L. Sacconi

17:35

Evening information and open end

M. v.d.Heyden

A. Janssen

 

19:30

Dinner

“Senaatszaal”, Academy Building


 

 

Friday, June 24 – 2nd Meeting Day

University of Utrecht, Academy Building

Address: Domplein 29, 3512 JE Utrecht

PI, Speaker

Poster Presenters

8:00

Clinical Trial Panel - Business Meeting

Meeting room 1 (members only)

8:00

Steering Committee Meeting – Business Meeting

Meeting room 2 (members only)

9:00

Session 5: Genetic arrhythmia modifiers

Chair: M. Zabel

9:00

WP 1: Analysis of genetic modifiers in a patient cohort receiving anti-arrhythmic ICD therapy (D1.2 m.36)

S. Lehnart

 

9:20

WP 2: HRC and JCN variants as arrhythmia modifiers in dilated cardiomyopathy (D2.1 & M2.1 each m.40)

L. Kranias

P2: D. Arvanitis

9:45

WP 17: C. elegans as a novel model for fast evaluation of human arrhythmia genes (D17.1 m.24)

A. Gottschalk

P17a: E. Fischer

P17b: see 9a

10:10

Module 8 update: administrative and financial issues

S. Broll

 

10:25

Open Access Publication

S. Lehnart, A. Janssen

10:30

Coffee Break

 

 

11:00

Session 6: Novel therapeutic strategies

Chair: S. Lehnart

11:00

WP15: Automated screening platform for drug compounds of Ca uptake and Ca release (D15.1 m.24)

G. Smith

P15a: L. Kattner

11:25

WP15: Combined NCX and late Na current inhibitor, and anti-arrhythmic potential (D15.5 m.24)

K. Sipido

G. Antoons

P15b: -

11:50

WP15: drug testing in large animal models of arrhythmia (D15.8)

S. Wijers

P15c: -

12:15

WP5: Low-Energy Control of Electrical Turbulence of the Heart (D5.3 & D5.4 m.24)

S. Luther

P5a: C. Richter

P5b: U. Parlitz

P5c: A. Squires

12:45

External Advisory Board

Feedback and recommendations

D. Eisner

 

13:00

On-site food and refreshments

 

 

13:30

Session 7: Na+ and Ca2+ dependent mechanisms

Chair: S. Jafri

13:30

WP 16: Na+/Ca2+ exchange activation in the dyad (D16.1 m.24); threshold of triggered APs (D16.2 m.24)

K. Sipido

G. Antoons

P16a: -

13:55

WP 13: Targeted-inducible NCX knockout in vivo

(D13.1 & D13.2 each m.42; M13.1 m.24)

S. Lehnart

P13a: S. Lehnart

14:20

WP8: Novel molecular mechanisms of arrhythmia susceptibility (D8.1 m.18/33, D8.4 m.30)

L. Kranias

P8a: E. Vafiadaki

14:45

WP 10: The cardiac Na+ channel and its role in arrhythmogenic remodeling (D10.1 m.24)

I. Baró

F. Charpentier

P10a: M. Derangeon

15:10

Coffee break

 

15:25

Session 8: In silico arrhythmia models

Chair: K. Sipido

15:50

WP 11: Arrhythmia modelling in the mouse, rabbit and human heart (D11.1 & D11.4 each m.18, D11.2 & D11.5 each m.24, D11.3 m.30)

F. Fenton

E. Bodenschatz

P11a: D. Hornung

16:15

WP 12: Understanding the molecular basis of calcium-entrained cardiac arrhythmia by GPU-enabled Monte Carlo Simulation (D12.1 m.18)

S. Jafri

P12a: S. Jafri

16:40

WP 12: Whole cell in silico modeling of Ca2+ triggers and translation to the action potential (D12.2 m.30)

W.J. Lederer

P12b: W.J. Lederer

17:05

Summary and to-dos: Year-2 report, Midterm Review, and Closing Remarks

S. Lehnart

 

18:00

End of General Assembly