EUTrigTreat General Assembly 2010

Glasgow, Scotland

 

Wednesday, July 7, Arrival & Get-Together

19:00

Casual Get-together
Dinner (Crowne Plaza Hotel Restaurant)

Business Meetings External Advisory Board and Steering Committee

 

Thursday, July 8 - FOCUS: Basic Sciences

General Assembly 1st Meeting Day

University of Glasgow, Wolfson Medical School Seminar Room

Speaker

Poster ID &

Presenter (t.b.d.)

9:00

Welcome address and Agenda

Glasgow – the group, the site and the whereabouts

S. Lehnart

G. Smith

 

9:10

Overview of the EUTrigTreat project
What did we achieve in the first 9 months?

S. Lehnart

 

9:20

Report from the Steering Committee

News from the science modules

E. Kranias

 

9:30

WP 7: Cardiac Na+ channel (NaV1.5) interactions with intercalated disk proteins and dystrophin: consequences of subcellular dysfunction (D7.1 m.12)

H. Abriel

P7:

9:55

WP 6: Imaging and analysis of conduction disease and arrhythmia triggers in situ (D6.1 m.24)

S. Lehnart

P6: N. Raad

10:20

Outcomes Session 1

 

 

10:30

Coffee Break

 

 

11:00

WP 8: HRC gene variants: pathophysiology of arrhythmogenic heart disease (D8.1 m.18)

E. Kranias

P8:

11:25

WP 3: Characterization of intracellular Ca2+ signals in the intact arrhythmogenic heart (D.3.1 m.24)

M. Mongillo

P3:

11:50

Outcomes Session 2

 

 

12:10

Lunch

 

 

13:10

Keynote Lecture: Regulation of intracellular calcium in the heart: from inotropy to arrhythmias

David Eisner chair G. Smith

 

14:15

Up-date on module 8: administrative issues & problem solving on demand,Decision regarding e-mail voting

A. Holzäpfel

E. Hoffmann

 

14:30

WP 9: Electrophysiological characterization of the C. elegans pharynx muscular pump, and SR-restricted Channelrhodopsin-2 to induce arrhythmia phenotypes (D9.1 m.12)

A. Gottschalk

P9:

14:55

WP 10: Mechanisms of cardiac Na+ channel (NaV1.5)  changes and cardiac remodeling (D10.1 m.24)

I. Baró

P10:

15:20

Outcomes Session 3

 

 

15:30

Coffee Break

 

 

16:00

WP 14: Expression profiling and bioinformatical analysis of CPVT mouse hearts (D14.1-4 m.32)

D. Sanoudou

S. Lehnart

P14: F. Matthes

16:25

WP 11: 3D arrhythmia modelling in the mouse and rabbit heart (D11.1 m.18 and D11.2 m.24)

E. Bodenschatz

F. Fenton

P11:

16:50

WP 12: Subcellular modelling of arrhythmia triggers (D12.1 m.18)

W.J. Lederer

P12:

17.00

Outcomes Session 4

 

 

17:15

 Poster Session I

All

 WPs 1st Day

19:30

Dinner Restaurant Stravaigain(28 Gibson St, Kelvinbridge, Glasgow G12 8NX)

         

Friday, July 9 – FOCUS: Translational and Clinical Sciences

General Assembly 2nd Meeting Day

University of Glasgow, Wolfson Medical School Seminar Room

PI, Speaker

Poster Presenters

9:00

WP 16: Na+/Ca2+ exchange activation in the dyad (D16.1 m.24); threshold of triggered APs (D16.2 m.24)

K. Sipido

G. Antoons

P16:

9:25

WP 13: Reversible, heart versus Purkinje-specific NCX knockout (D13.1 and D13.2 both m.42; M13.1 m.24)

S. Lehnart

 

P13: A. Kaul

9:50

Outcomes Session 5

 

 

10:00

Coffee Break

 

 

10:20

WP 15: Retinal analogues (D15.4 m.12); cell-based drug screening for Ca2+ uptake/release (D15.1 m.24); combined NCX and INa,late inhibitor (D15.5 m.24)

R. Varkevisser

P15:

10:45

WP 17: Engineering of human arrhythmia gene mutations in C.elegans (D17.1 m.24)

A. Gottschalk

P17:

11:10

Outcomes Session 6

 

 

11:15

Poster Session II

 All

 WPs 2nd Day

12:00

Clinical Trial & Ethics Panel Meeting

Panel members only

12:00

Steering Committee Meeting

SC members only

12:30

Lunch

 

 

13:30

WP 1: Multi-center patient cohort enrolment (632 patients D.1.1 m.30) and cardiac electrophysiological risk analysis including genetic and environmental modulators (D.1.2 m.36)

M. Zabel

P1: Seegers

13:55

WP 2: Identification of new genetic HRC and JCN variants (D2.1 and M2.1 both m.40)

L. Kranias, S. Lehnart

P2:

14:20

Outcomes Session 7

 

 

14:30

Coffee break

 

15:00

WP5: New diagnostic tools to quantify arrhythmia dynamics and low-energy control of arrhythmias by novel device therapy (D5.1 m.12, D5.2 m.18)

S. Luther

P5:

15:25

WP4: Dynamics of T wave alternans and heart rate during arrhythmia initiation (D4.1 m.24, D4.2 m.24)

G. Smith

P4:

15:50

Outcomes Session 8

 

 

16:00

External Advisory Board Feedback and recommendations

Board Members

 

16:20

Closing Remarks

S. Lehnart

 

16:30

End of General Assembly (departure)

 

 

Note

Clinical Trial partners continue, please refer to page 3.

 

 

Friday, July 9 – Clinical Trial Workshop Part I

 

Clinical Trial Workshop Part I

University of Glasgow, Wolfson Medical School Seminar Room

PI, Speaker

17:00

Clinical Trial Developments incl. projection of patient recruitment

M. Zabel

17:20

Discussion

All

17:40

Statistical Methods to be used in the Clinical Study

T. Friede

18:00

Clinical Use of CE marked MAP Catheter

M. Zabel

18:20

Scientific Sub-study BVR

M. Vos

18:40

End of Clinical Trial Workshop Part I

 

20:00

Casual Get-together & Dinner (t.b.a., at own expense)

 

 

Saturday, July 10 - Clinical Trial Workshop Part II

 

Cont.

Clinical Trial Workshop

  

08:45

Genetic Testing: Update on Logistics and Strategies

J. Brockmöller

09:10

Noninvasive electrophysiological testing: first experiences

J. Seegers

09:30

Scientific Sub-study TWA

G. Smith

09:50

Discussion & Adjourn

All

10:30

Light refreshments; Departure