Biomedical Research Foundation Academy of Athens


Short describtion of institute and department

The BRFAA is a non-profit institute dedicated to conducting research in the main areas of Biology and Medicine at the molecular, biochemical and cellular level. It accommodates state-of-the-art facilities over a 25.000 m2 area, currently hosting over 50 research teams and 400 employees. Within its 4 years in full operation, the rigorous research performed at BRFAA is already receiving international recognition, with over 100 publications to high impact international scientific journals, and most importantly the successful attraction of over 16,000,000 € of competitive research grants from national, European and international funding organizations. The Molecular Biology Division of BRFAA focuses on the elucidation of the molecular mechanisms and pathways underlying cardiac muscle function under physiological and patho-physiological conditions. Special emphasis is placed on uncovering the "cross talk" between impairment of calcium homeostasis and cardiac remodelling, as it relates to the onset of cardiac arrhythmias, hypertrophy and its transition to heart failure.

The principal investigator Prof. E. Kranias is also chairing the Department of Pharmacology & Cell Biophysics - Cardiovascular Center of Excellence at the University of Cincinnati, College of Medicine, USA.

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Contribution to the project

Our team investigates arrhythmia mechanisms in the mouse models HRC-S96A knockin, Junctin knockout in WP8; contributes mutation screening in patients in WP 2; investigates genetic and environmental, drug models in WP14; and contributes to the development of novel anti-arrhythmic drug testing in mouse models in WP16.

 

Biomedical Research Foundation Academy of Athens

Molecular Biology - Biomedical Research Foundation

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Biomedical Research Prof. E. Kranias

College of Medicine, University of Cincinnati, USA

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