Johann Wolfgang Goethe-University - GUF


Short Description of the institution and department guf logo

Goethe-University is a major German University (~31.000 students in all disciplines). The lab is situated on the new science Campus Riedberg, Department of Biochemistry, Chemistry and Pharmacy, in the Institute of Biochemistry. We are supported by the Excellence Cluster “Macromolecular Assemblies”, awarded to Goethe-University by the German Research Council (DFG) in 2006. A tenured W2 professorship for the team leader is planned for 2009.

Institute of Biochemistry

Environment: The Institute has 4 groups (incl. Gottschalk): Tampé studies membrane transport and nanotechnology on solid surfaces. Ludwig studies mitochondrial biology (molecular / structural). Pos works on membrane protein structure. The Institute is linked to the Institute of Biophysics, with three biological NMR groups: Dötsch, Glaubitz, Güntert. >40 neuroscience groups at Goethe-University and the Max Planck Institute (MPI) for Brain Research connect by the Interdisciplinary Center for Neurosciences. University Medicine has a strong program in cardiovascular research, including the Excellence Cluster “Cardio-Pulmonary System”. At MPI Brain Research, Betz works on inhibitory synapse biogenesis and implementation of optogenetic tools in the mouse, together with Wässle - studying vision and retinal function; Singer studies higher brain function. At the MPI for Biophysics, Bamberg first considered ChR2 & NpHR as optogenetic tools; with whom we established those in C. elegans, Michel (Nobel Laureate): Membrane Protein Structure. Kühlbrandt: Structural Biology, Electronmicroscopy. Mombaerts: Olfactory receptors, mouse genetics.

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Contribution to the project

Implement C. elegans muscular tissues as arrhythmia model, to study human arrhythmia genes and mutations in this system (with Lehnart, Mongillo, Kranias). C. elegans screening platform for anti-arrhythmia drugs with Endotherm. Implement optical arrhythmia trigger and spread, and establish ER-restricted ChR2 as optically induced Ca2+ leak. Optogenetic tools will be transferred to mouse cardiac cells and whole heart with Lehnart and Mongillo.

 

Johann Wolfgang Goethe-University  - GUF

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Additional information on the model organism C. elegans

Stanford

Wormbase

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Wormbook

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Wormatlas

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